reviewNew England Journal of MedicineJul 13, 2005GREEN OA

Tyrosine Kinases as Targets for Cancer Therapy

DSDaniela S. KrauseRARichard A. Van Etten

Tufts Medical Center

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Abstract

Tyrosine kinases, enzymes that catalyze the transfer of phosphate from ATP to tyrosine residues in polypeptides, are ubiquitous, numerous, and of considerable clinical interest because they participate in the development of cancer and have become choice targets for therapeutic intervention. This comprehensive review discusses the molecular and clinical aspects of tyrosine kinases.

Citation impact

1,378
total citations
FWCI
37.73
Percentile
100%
References
122
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Tyrosine kinase
  • Receptor tyrosine kinase
  • Tyrosine
  • Medicine
  • Kinase
  • Protein tyrosine phosphatase
  • Cancer
  • Protein-Tyrosine Kinases
UN Sustainable Development Goals
  • Good health and well-being
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