Guidelines of the American College of Obstetricians and Gynecologists for exercise during pregnancy and the postpartum period

The cardiac action potential is generated by a concerted action of different ion channels and transporters. Dysfunction of any of these membrane proteins can give rise to cardiac arrhythmias, which is particularly true for the repolarizing potassium channels. We suggest that an increased repolarization current could be a new antiarrhythmic principle, because it possibly would attenuate afterdepolarizations, ischemic leak currents, and re-entry phenomena. Repolarization of the cardiac myocytes is crucially dependent on the late rapid delayed rectifier current (IKr) conducted by ether-a-go-go-related gene (ERG) potassium channels. We have developed the diphenylurea compound…