Genome Sequencing Highlights the Dynamic Early History of Dogs
University of California, Los Angeles · Cornell University · +13 more institutions
Abstract
To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of the three putative centers of dog domestication, two basal dog lineages (Basenji and Dingo) and a golden jackal as an outgroup. Analysis of these sequences supports a demographic model in which dogs and wolves diverged through a dynamic process involving population bottlenecks in both lineages and post-divergence gene flow. In dogs, the domestication bottleneck involved at least a 16-fold reduction in population size, a much more severe bottleneck than estimated previously. A sharp bottleneck in wolves occurred soon after…
Citation impact
- FWCI
- 49.08
- Percentile
- 100%
- References
- 38
Authors
30Topics & keywords
- Domestication
- Biology
- Dingo
- Population bottleneck
- Population
- Evolutionary biology
- Population genomics
- Jackal
- Zero hunger
Funding
- NSNational Science FoundationAwards: 0948510, EF-1021397, 1021397, 0905784
- UOUniversity of California Institute for Mexico and the United StatesAward: 213627
- CNConsejo Nacional de Ciencia y Tecnología
- TATel Aviv University
- MDMinisterio de Ciencia e InnovaciónAward: BFU2011-28549
- UDUniversità di Bologna
- NINational Institutes of HealthAwards: HG002536, CA009056, NIH T32, T32 HG002536, T32 CA009056
- NSNational Science and Technology Planning ProjectAward: 2012BAC01B06
- NHNational Human Genome Research InstituteAward: HG002536
- NINational Institute of General Medical SciencesAward: GM102192