Urine NGAL Predicts Severity of Acute Kidney Injury After Cardiac Surgery
University of Cincinnati · Abbott (United States) · +2 more institutions
Abstract
AKI developed in 99 patients (51%), but the diagnosis using serum creatinine was delayed by 2 to 3 d after CPB. In contrast, mean urine NGAL levels increased 15-fold within 2 h and by 25-fold at 4 and 6 h after CPB. For the 2-h urine NGAL measurement, the area under the curve was 0.95, sensitivity was 0.82, and the specificity was 0.90 for prediction of AKI using a cutoff value of 100 ng/ml. The 2-h urine NGAL levels correlated with severity and duration of AKI, length of stay, dialysis requirement, and death.
Accurate measurements of urine NGAL are obtained using the ARCHITECT platform. Urine NGAL is an early predictive biomarker of AKI severity after CPB.
Citation impact
- FWCI
- 32.62
- Percentile
- 100%
- References
- 41
Authors
10- MBMichael BennettCorresponding
University of Cincinnati, Abbott (United States), Columbia University, Cincinnati Children's Hospital Medical Center
- CLCatherine L. Dent
University of Cincinnati, Abbott (United States), Columbia University, Cincinnati Children's Hospital Medical Center
- QMQing Ma
Abbott (United States), Cincinnati Children's Hospital Medical Center, University of Cincinnati, Columbia University
- SDSudha Dastrala
Columbia University, Cincinnati Children's Hospital Medical Center, Abbott (United States), University of Cincinnati
- FCFrank C. Grenier
Abbott (United States), Cincinnati Children's Hospital Medical Center, University of Cincinnati, Columbia University
Topics & keywords
- Medicine
- Urine
- Acute kidney injury
- Creatinine
- Lipocalin
- Cardiopulmonary bypass
- Urology
- Biomarker
- Good health and well-being