Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes
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Abstract
The current study addresses a novel hypothesis of subcellular distribution of mitochondrial dysfunction in skeletal muscle in type 2 diabetes. Vastus lateralis muscle was obtained by percutaneous biopsy from 11 volunteers with type 2 diabetes; 12 age-, sex-, and weight-matched obese sedentary nondiabetic volunteers; and 8 lean volunteers. Subsarcolemmal and intermyofibrillar mitochondrial fractions were isolated by differential centrifugation and digestion techniques. Overall electron transport chain activity was similar in type 2 diabetic and obese subjects, but subsarcolemmal mitochondria electron transport chain activity was reduced in type 2 diabetic subjects (0.017 +/- 0.003 vs. 0.034 +/- 0.007 units/mU…
Citation impact
883
total citations
- FWCI
- 26.10
- Percentile
- 100%
- References
- 48
Citations per year
Authors
6Topics & keywords
Topics
Keywords
- Internal medicine
- Endocrinology
- Type 2 diabetes
- Mitochondrion
- Diabetes mellitus
- Muscle biopsy
- Skeletal muscle
- Insulin resistance
UN Sustainable Development Goals
- Good health and well-being
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