Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor
St George's, University of London · University of Liverpool
Abstract
Extracellular matrices (ECM) are secreted molecules that constitute the cell microenvironment, composed of a dynamic and complex array of glycoproteins, collagens, glycosaminoglycans and proteoglycans. ECM provides the bulk, shape and strength of many tissues in vivo, such as basement membrane, bone and cartilage. In vitro, most animal cells can only grow when they are attached to surfaces through ECM. ECM is also the substrate for cell migration. However, ECM provides much more than just mechanical and structural support, with implications in developmental patterning, stem cell niches and cancer. ECM imparts spatial context for signalling events by various cell surface growth factor receptors and adhesion…
Citation impact
- FWCI
- 32.61
- Percentile
- 100%
- References
- 143
Authors
3Topics & keywords
- Cell biology
- Extracellular matrix
- Integrin
- Cell adhesion
- Cell adhesion molecule
- Biology
- Growth factor
- Chemistry