articleAngewandte Chemie International EditionFeb 9, 2007Closed access

siRNA Delivery into Human T Cells and Primary Cells with Carbon‐Nanotube Transporters

Stanford University · VA Palo Alto Health Care System

PubMed
Indexed incrossrefpubmed

Abstract

Special delivery: Functionalized single-walled nanotubes (SWNT) can be used as molecular transporters to shuttle short interfering RNA (siRNA) into human T cells and primary cells and silence the expression of HIV-specific cell-surface receptors and coreceptors (see picture; scale bars 40 μm). This silencing effect, known to block HIV viral entry and reduce infection, is superior to that observed with conventional liposome-based nonviral delivery agents.

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664
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Authors

4

Topics & keywords

Keywords
  • Small interfering RNA
  • Gene silencing
  • Carbon nanotube
  • Cell biology
  • Cell
  • Human immunodeficiency virus (HIV)
  • Drug delivery
  • Transporter
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