siRNA Delivery into Human T Cells and Primary Cells with Carbon‐Nanotube Transporters
Stanford University · VA Palo Alto Health Care System
Indexed incrossrefpubmed
Abstract
Special delivery: Functionalized single-walled nanotubes (SWNT) can be used as molecular transporters to shuttle short interfering RNA (siRNA) into human T cells and primary cells and silence the expression of HIV-specific cell-surface receptors and coreceptors (see picture; scale bars 40 μm). This silencing effect, known to block HIV viral entry and reduce infection, is superior to that observed with conventional liposome-based nonviral delivery agents.
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664
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Authors
4Topics & keywords
Topics
Keywords
- Small interfering RNA
- Gene silencing
- Carbon nanotube
- Cell biology
- Cell
- Human immunodeficiency virus (HIV)
- Drug delivery
- Transporter
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