Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells
Suzhou Institute of Nano-tech and Nano-bionics · Chinese Academy of Sciences · +1 more institution
Abstract
Neural stem cell (NSC) based therapy provides a promising approach for neural regeneration. For the success of NSC clinical application, a scaffold is required to provide three-dimensional (3D) cell growth microenvironments and appropriate synergistic cell guidance cues. Here, we report the first utilization of graphene foam, a 3D porous structure, as a novel scaffold for NSCs in vitro. It was found that three-dimensional graphene foams (3D-GFs) can not only support NSC growth, but also keep cell at an active proliferation state with upregulation of Ki67 expression than that of two-dimensional graphene films. Meanwhile, phenotypic analysis indicated that 3D-GFs can enhance the NSC differentiation towards…
Citation impact
- FWCI
- 33.67
- Percentile
- 100%
- References
- 28
Authors
10- NLNing LiCorresponding
Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences
- QZQi Zhang
Chinese Academy of Sciences, Suzhou Institute of Nano-tech and Nano-bionics
- SGSong Gao
Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences
- SQSong Qin
Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences
- RHRong Huang
Chinese Academy of Sciences, Suzhou Institute of Nano-tech and Nano-bionics, University of Chinese Academy of Sciences
Topics & keywords
- Scaffold
- Neural stem cell
- Neural tissue engineering
- Graphene
- Materials science
- Stem cell
- Nanotechnology
- Cell biology