articleNew England Journal of MedicineOct 1, 2014BRONZE OA

Goal-Directed Resuscitation for Patients with Early Septic Shock

TAThe ARISE Investigators and the ANZICS Clinical Trials Group
PubMed
Indexed incrossrefpubmed

Abstract

Background

Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease mortality among patients presenting to the emergency department with septic shock. However, its effectiveness is uncertain.

Methods

In this trial conducted at 51 centers (mostly in Australia or New Zealand), we randomly assigned patients presenting to the emergency department with early septic shock to receive either EGDT or usual care. The primary outcome was all-cause mortality within 90 days after randomization.

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Authors

1
  • TA
    The ARISE Investigators and the ANZICS Clinical Trials GroupCorresponding

Topics & keywords

Topics
Keywords
  • Early goal-directed therapy
  • Medicine
  • Septic shock
  • Resuscitation
  • Sepsis
  • Shock (circulatory)
  • Surviving Sepsis Campaign
  • Intensive care medicine
UN Sustainable Development Goals
  • Good health and well-being
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