Intrapulmonary Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-Induced Acute Lung Injury in Mice

Gupta, Naveen; Su, Xiao; Popov, B. V.; Lee, Jae Woo; Serikov, Vladimir B.; Matthay, Michael A.

doi:10.4049/jimmunol.179.3.1855

articleThe Journal of ImmunologyAug 1, 2007BRONZE OA

Intrapulmonary Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-Induced Acute Lung Injury in Mice

NGNaveen Gupta XSXiao Su BVB. V. Popov JWJae Woo Lee VBVladimir B. Serikov

University of California, San Francisco · Oaklands Hospital

PubMed

Indexed incrossrefpubmed

Abstract

Recent in vivo and in vitro work suggests that mesenchymal stem cells (MSC) have anti-inflammatory properties. In this study, we tested the effect of administering MSC directly into the airspaces of the lung 4 h after the intrapulmonary administration of Escherichia coli endotoxin (5 mg/kg). MSC increased survival compared with PBS-treated control mice at 48 h (80 vs 42%; p

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Topics & keywords

Topics

Keywords

Bronchoalveolar lavage
Mesenchymal stem cell
Medicine
Proinflammatory cytokine
Lung
Bone marrow
In vivo
Pulmonary edema

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