Evidence for a release of brain‐derived neurotrophic factor from the brain during exercise

Brain-derived neurotrophic factor (BDNF) has an important role in regulating maintenance, growth and survival of neurons. However, the main source of circulating BDNF in response to exercise is unknown. To identify whether the brain is a source of BDNF during exercise, eight volunteers rowed for 4 h while simultaneous blood samples were obtained from the radial artery and the internal jugular vein. To further identify putative cerebral region(s) responsible for BDNF release, mouse brains were dissected and analysed for BDNF mRNA expression following treadmill exercise. In humans, a BDNF release from the brain was observed at rest (P

• SO
  Sundhed og Sygdom, Det Frie Forskningsråd
• VG
  Vedecká Grantová Agentúra MŠVVaŠ SR a SAV