Deconstructing the molecular portraits of breast cancer

Breast cancer is a heterogeneous disease in terms of histology, therapeutic response, dissemination patterns to distant sites, and patient outcomes. Global gene expression analyses using high-throughput technologies have helped to explain much of this heterogeneity and provided important new classifications of cancer patients. In the last decade, genomic studies have established five breast cancer intrinsic subtypes (Luminal A, Luminal B, HER2-enriched, Claudin-low, Basal-like) and a Normal Breast-like group. In this review, we dissect the most recent data on this genomic classification of breast cancer with a special focus on the Claudin-low subtype, which appears enriched for mesenchymal and stem cell…

• BC
  Breast Cancer Research Foundation
• VF
  V Foundation for Cancer Research
• UD
  Universitat de Barcelona
• UA
  Universitat Autònoma de Barcelona
• UO
  University of North Carolina at Chapel Hill

  Award: P50-CA58223-09A1
• NC
  National Cancer Institute

  Awards: P50-CA58223, P50-CA58223-09A1, CA58223