-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease
University of Melbourne · Monash University · +2 more institutions
Abstract
Beta-amyloid (Abeta) deposition is pathognomic for Alzheimer's disease (AD), but may occur in normal elderly people without apparent cognitive effect. Episodic memory impairment is an early and prominent sign of AD, but its relationship with Abeta burden in non-demented persons and in AD patients is unclear. We examined this relationship using 11C-PIB-PET as a quantitative marker of Abeta burden in vivo in healthy ageing (HA), mild cognitive impairment (MCI) and AD. Thirty-one AD, 33 MCI and 32 HA participants completed neuropsychological assessment and a 11C-PIB-PET brain scan. Multiple linear regression analyses were conducted relating episodic memory performance and other cognitive functions to Abeta…
Citation impact
- FWCI
- 29.64
- Percentile
- 100%
- References
- 58
Authors
10- KEKerryn E. PikeCorresponding
University of Melbourne, Monash University, Mental Health Research Institute, Austin Health
- GSGreg Savage
Austin Health, Mental Health Research Institute, University of Melbourne, Monash University
- VVVL Villemagne
University of Melbourne, Monash University, Mental Health Research Institute, Austin Health
- SNSally Ng
Monash University, Austin Health, Mental Health Research Institute, University of Melbourne
- SMSimon Moss
Monash University, University of Melbourne, Mental Health Research Institute, Austin Health
Topics & keywords
- Episodic memory
- Pittsburgh compound B
- Alzheimer's disease
- Dementia
- Psychology
- Disease
- Cognition
- Neuropsychology
- Good health and well-being