Multiple reference genomes and transcriptomes for Arabidopsis thaliana

Genetic differences between Arabidopsis thaliana accessions underlie the plant’s extensive phenotypic variation, and until now these have been interpreted largely in the context of the annotated reference accession Col-0. Here we report the sequencing, assembly and annotation of the genomes of 18 natural A. thaliana accessions, and their transcriptomes. When assessed on the basis of the reference annotation, one-third of protein-coding genes are predicted to be disrupted in at least one accession. However, re-annotation of each genome revealed that alternative gene models often restore coding potential. Gene expression in seedlings differed for nearly half of expressed genes and was frequently associated with…

• NS
  National Science Foundation

  Award: 0820985
• WT
  Wellcome Trust

  Awards: 090532, 090532/Z/09/Z, 090532/Z/09/
• DF
  Deutsche Forschungsgemeinschaft
• KA
  King Abdullah University of Science and Technology

  Award: KUK-I1-002-03
• M
  Max-Planck-Gesellschaft
• DF
  Directorate for Biological Sciences
• BA
  Biotechnology and Biological Sciences Research Council

  Awards: BB/F022697/1, BB/D016029/1, BB/F022697/1, BB/F019793/1, BB/F020759/1, BB/D016029/2, 090532/Z/09/Z, BB/F019793/1, BB/D016029/2, BB/F020759/1