Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease
Franklin University · Charité - Universitätsmedizin Berlin
Indexed incrossrefpubmed
Abstract
Background
Epithelial barrier function is impaired in Crohn's disease.
Aim
To define the underlying cellular mechanisms with special attention to tight junctions.
Citation impact
1,188
total citations
- FWCI
- 28.24
- Percentile
- 100%
- References
- 51
Citations per year
Authors
10Topics & keywords
Topics
Keywords
- Tight junction
- Claudin
- Occludin
- Barrier function
- Downregulation and upregulation
- Cell junction
- Pathology
- Intestinal mucosa
No related works found for this paper.