Emerging insights into the molecular and cellular basis of glioblastoma
Broad Institute · Harvard University · +10 more institutions
Abstract
Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive multiplatform genomic characterization has provided a higher-resolution picture of the molecular alterations underlying this disease. These studies provide the emerging view that "glioblastoma" represents several histologically similar yet molecularly heterogeneous diseases, which influences taxonomic classification systems, prognosis, and therapeutic decisions.
Citation impact
- FWCI
- —
- Percentile
- —
- References
- 371
Authors
17- GPGavin P. DunnCorresponding
Broad Institute, Harvard University, Massachusetts General Hospital, Dana-Farber Cancer Institute
- MLMikael L. Rinne
Broad Institute, Harvard University, Center for Neuro-Oncology, Dana-Farber Cancer Institute
- JWJill Wykosky
Ludwig Cancer Research, Ludwig Cancer Research
- GGGiannicola Genovese
Harvard University, Dana-Farber Cancer Institute
- SNSteven N. Quayle
Harvard University, Dana-Farber Cancer Institute
Topics & keywords
- Biology
- Glioblastoma
- Computational biology
- Disease
- Cancer research
- Pathology
- Good health and well-being
Funding
- ABAmerican Brain Tumor Association
- NFNational Foundation for Cancer Research
- GFGoldhirsh Foundation
- SFSontag Foundation
- BABen and Catherine Ivy Foundation
- BSBrain Science Foundation
- NINational Institutes of HealthAward: PO1 CA117969
- NCNational Cancer InstituteAward: PO1 CA117969
- NINational Institute of Neurological Disorders and Stroke