Epithelial‐mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients

Epithelial-mesenchymal transition (EMT) is a reversible and dynamic process hypothesized to be co-opted by carcinoma during invasion and metastasis. Yet, there is still no quantitative measure to assess the interplay between EMT and cancer progression. Here, we derived a method for universal EMT scoring from cancer-specific transcriptomic EMT signatures of ovarian, breast, bladder, lung, colorectal and gastric cancers. We show that EMT scoring exhibits good correlation with previously published, cancer-specific EMT signatures. This universal and quantitative EMT scoring was used to establish an EMT spectrum across various cancers, with good correlation noted between cell lines and tumours. We show correlations…

• NR
  National Research Foundation
• NU
  National University of Singapore
• NR
  National Research Foundation Singapore
• MR
  Medical Research Council
• NM
  National Medical Research Council

  Award: CG12Aug12
• IO
  Institute of Molecular and Cell Biology
• CS
  Cancer Science Institute of Singapore, National University of Singapore