Micafungin versus Fluconazole for Prophylaxis against Invasive Fungal Infections during Neutropenia in Patients Undergoing Hematopoietic Stem Cell Transplantation

Burik, J.-A. H. van; Ratanatharathorn, V.; Stepan, Daniel E.; Miller, Carole B.; Lipton, Jeffrey H.; Vesole, David H.; Bunin, Nancy; Wall, Donna A.; Hiemenz, J.; Satoi, Yoichi; Lee, J. M.; Walsh, Thomas J.

doi:10.1086/422312

articleClinical Infectious DiseasesNov 2, 2004BRONZE OA

Micafungin versus Fluconazole for Prophylaxis against Invasive Fungal Infections during Neutropenia in Patients Undergoing Hematopoietic Stem Cell Transplantation

JHJ.-A. H. van Burik VRV. Ratanatharathorn DEDaniel E. Stepan CBCarole B. Miller JHJeffrey H. Lipton

University of Minnesota System · University of Michigan · +9 more institutions

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Abstract

We hypothesized that chemoprophylaxis with the echinocandin micafungin would be an effective agent for antifungal prophylaxis during neutropenia in patients undergoing hematopoietic stem cell transplantation (HSCT). We therefore conducted a randomized, double-blind, multi-institutional, comparative phase III trial, involving 882 adult and pediatric patients, of 50 mg of micafungin (1 mg/kg for patients weighing

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Topics & keywords

Topics

Keywords

Micafungin
Fluconazole
Medicine
Neutropenia
Echinocandin
Hematopoietic stem cell transplantation
Internal medicine
Transplantation

UN Sustainable Development Goals

Good health and well-being

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