Dissecting the genomic complexity underlying medulloblastoma

Jones, David; Jäger, Natalie; Kool, Marcel; Zichner, Thomas; Hutter, Barbara; Sultan, Marc; Cho, Yoon‐Jae; Pugh, Trevor J.; Hovestadt, Volker; Stütz, Adrian M.; Rausch, Tobias; Warnatz, Hans-Jörg; Ryzhova, Marina; Bender, Sebastian; Sturm, Dominik; Pleier, Sabrina; Cin, Huriye; Pfaff, Elke; Sieber, Laura; Wittmann, Andrea; Remke, Marc; Witt, Hendrik; Hutter, Sonja; Tzaridis, Theophilos; Weischenfeldt, Joachim; Raeder, Benjamin; Avci, Meryem; Amstislavskiy, Vyacheslav; Zapatka, Marc; Weber, Ursula; Wang, Qi; Lasitschka, Bärbel; Bartholomae, Cynthia C.; Schmidt, Manfred; Kalle, Christof von; Ast, Volker; Lawerenz, Chris; Eils, Jürgen; Kabbe, Rolf; Beneš, Vladimı́r; Sluis, Peter van; Köster, Jan; Volckmann, Richard; Shih, David; Betts, Matthew J.; Russell, Robert B.; Coco, Simona; Tonini, Gian Paolo; Schüller, Ulrich; Hans, Volkmar; Graf, Norbert; Kim, Yoo-Jin; Monoranu, Camelia; Roggendorf, Wolfgang; Unterberg, Andreas; Herold‐Mende, Christel; Milde, Till; Kulozik, Andreas E.; Deimling, Andreas von; Witt, Olaf; Maass, Eberhard; Rößler, Jochen; Ebinger, Martin; Schuhmann, Martin U.; Frühwald, Michael C.; Hasselblatt, Martin; Jabado, Nada; Rutkowski, Stefan; Bueren, André O. von; Williamson, Dan; Clifford, Steven C.; McCabe, Martin G.; Collins, V. Peter; Wolf, Stephan; Wiemann, Stefan; Lehrach, Hans; Brors, Benedikt; Scheurlen, Wolfram; Felsberg, Jörg; Reifenberger, Guido; Northcott, Paul A.; Taylor, Michael D.; Meyerson, Matthew; Pomeroy, Scott L.; Yaspo, Marie‐Laure; Korbel, Jan O.; Korshunov, Andrey; Eils, Roland; Pfister, Stefan M.; Lichter, Peter

doi:10.1038/nature11284

articleNatureJul 24, 2012HYBRID OA

Dissecting the genomic complexity underlying medulloblastoma

DJDavid Jones NJNatalie Jäger MKMarcel Kool TZThomas Zichner BHBarbara Hutter

German Cancer Research Center · Heidelberg University · +34 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Medulloblastoma is the most common brain tumour in children; using whole-genome sequencing of tumour samples the authors show that the clinically challenging Group 3 and 4 tumours can be tetraploid, and reveal the expression of the first medulloblastoma fusion genes identified. Medulloblastoma is the most common malignant brain tumour in children. Four papers published in the 2 August 2012 issue of Nature use whole-genome and other sequencing techniques to produce a detailed picture of the genetics and genomics of this condition. Notable findings include the identification of recurrent mutations in genes not previously implicated in medulloblastoma, with significant genetic differences associated with the four…

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Topics & keywords

Topics

Keywords

Medulloblastoma
Biology
Wnt signaling pathway
PTCH1
Sonic hedgehog
Hedgehog
Cancer research
Gene

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