Detection of nonneutral substitution rates on mammalian phylogenies

Methods for detecting nucleotide substitution rates that are faster or slower than expected under neutral drift are widely used to identify candidate functional elements in genomic sequences. However, most existing methods consider either reductions (conservation) or increases (acceleration) in rate but not both, or assume that selection acts uniformly across the branches of a phylogeny. Here we examine the more general problem of detecting departures from the neutral rate of substitution in either direction, possibly in a clade-specific manner. We consider four statistical, phylogenetic tests for addressing this problem: a likelihood ratio test, a score test, a test based on exact distributions of numbers of…

• NS
  National Science Foundation
• DA
  David and Lucile Packard Foundation
• AP
  Alfred P. Sloan Foundation
• NI
  National Institute of General Medical Sciences