A distinct “side population” of cells with high drug efflux capacity in human tumor cells
Houston Methodist · Baylor College of Medicine · +6 more institutions
Abstract
A subset of stem cells, termed the "side population" (SP), has been identified in several tissues in mammalian species. These cells maintain a high efflux capability for antimitotic drugs. We have investigated whether functionally equivalent stem cells also may be detected in human cancers. We initially examined primary tumor cells from 23 patients with neuroblastoma and cell lines derived from a range of other tumors. A distinct SP was found in neuroblastoma cells from 15 of 23 patients (65%). The SP was capable of sustained expansion ex vivo and showed evidence for asymmetric division, generating both SP and non-SP progeny. These cells also expressed high levels of ABCG2 and ABCA3 transporter genes and had a…
Citation impact
- FWCI
- 30.67
- Percentile
- 100%
- References
- 44
Authors
8- CHCharlotte Hirschmann-JaxCorresponding
Houston Methodist, Baylor College of Medicine, University Medical Center, Düsseldorf University Hospital, Methodist Hospital, Methodist Children’s Hospital, Texas Children's Hospital, Heinrich Heine University Düsseldorf
- AEAngela E. Foster
Baylor College of Medicine, University Medical Center, Düsseldorf University Hospital, Methodist Hospital, Texas Children's Hospital, Heinrich Heine University Düsseldorf
- GWGerald Wulf
Baylor College of Medicine, University Medical Center, Düsseldorf University Hospital, Methodist Hospital, Texas Children's Hospital, Heinrich Heine University Düsseldorf
- JGJed G. Nuchtern
Baylor College of Medicine, University Medical Center, Düsseldorf University Hospital, Methodist Hospital, Texas Children's Hospital, Heinrich Heine University Düsseldorf
- TJThomas Jax
Baylor College of Medicine, University Medical Center, Düsseldorf University Hospital, Methodist Hospital, Texas Children's Hospital, Heinrich Heine University Düsseldorf
Topics & keywords
- Side population
- Cancer stem cell
- Efflux
- Biology
- Cancer research
- Cytotoxic T cell
- Mitoxantrone
- Abcg2
- Good health and well-being