Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system
Centre National de la Recherche Scientifique · Université Paris-Est Créteil · +6 more institutions
Abstract
The reason for the high frequency of depression and anxiety in Parkinson's disease is poorly understood. Degeneration of neurotransmitter systems other than dopamine might play a specific role in the occurrence of these affective disorders. We used [11C]RTI-32 PET, an in vivo marker of both dopamine and noradrenaline transporter binding, to localize differences between depressed and non-depressed patients. We studied eight and 12 Parkinson's disease patients with and without a history of depression matched for age, disease duration and doses of antiparkinsonian medication. The depressed Parkinson's disease cohort had lower [11C]RTI-32 binding than non-depressed Parkinson's disease cases in the locus coeruleus…
Citation impact
- FWCI
- 21.51
- Percentile
- 100%
- References
- 57
Authors
5- PRPhilippe RémyCorresponding
Centre National de la Recherche Scientifique, Université Paris-Est Créteil, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Hammersmith Hospital, Centre Hospitalier Universitaire Henri-Mondor, Institut d'Imagerie Biomédicale
- MDM Doder
Hammersmith Hospital
- AJAndrew J. Lees
National Hospital for Neurology and Neurosurgery, University College London
- NTN. Turjanski
Hammersmith Hospital
- DJDavid J. Brooks
Hammersmith Hospital
Topics & keywords
- Dopamine
- Parkinson's disease
- Psychology
- Locus coeruleus
- Striatum
- Amygdala
- Internal medicine
- Neuroscience
- Good health and well-being