Association of Non-alcoholic Fatty Liver Disease with Chronic Kidney Disease: A Systematic Review and Meta-analysis

BACKGROUND: Chronic kidney disease (CKD) is a frequent, under-recognized condition and a risk factor for renal failure and cardiovascular disease. Increasing evidence connects non-alcoholic fatty liver disease (NAFLD) to CKD. We conducted a meta-analysis to determine whether the presence and severity of NAFLD are associated with the presence and severity of CKD. METHODS AND FINDINGS: English and non-English articles from international online databases from 1980 through January 31, 2014 were searched. Observational studies assessing NAFLD by histology, imaging, or biochemistry and defining CKD as either estimated glomerular filtration rate (eGFR)

• BF
  Bundesministerium für Bildung und Forschung

  Award: 03152061A
• CU
  Chinese University of Hong Kong
• AU
  Aristotle University of Thessaloniki
• SA
  Science and Technology Program of Hunan Province
• AM
  Anschutz Medical Campus, University of Colorado
• NH
  National Health and Medical Research Council

  Awards: 1049857, 1053206, 632630