Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents
Brigham and Women's Hospital · Fox Chase Cancer Center · +5 more institutions
Abstract
UNLABELLED: DNA repair competency is one determinant of sensitivity to certain chemotherapy drugs, such as cisplatin. Cancer cells with intact DNA repair can avoid the accumulation of genome damage during growth and also can repair platinum-induced DNA damage. We sought genomic signatures indicative of defective DNA repair in cell lines and tumors and correlated these signatures to platinum sensitivity. The number of subchromosomal regions with allelic imbalance extending to the telomere (N(tAI)) predicted cisplatin sensitivity in vitro and pathologic response to preoperative cisplatin treatment in patients with triple-negative breast cancer (TNBC). In serous ovarian cancer treated with platinum-based…
Citation impact
- FWCI
- 8.53
- Percentile
- 100%
- References
- 46
Authors
16- NJNicolai J. BirkbakCorresponding
Brigham and Women's Hospital, Fox Chase Cancer Center, Beth Israel Deaconess Medical Center, Harvard–MIT Division of Health Sciences and Technology, Dana-Farber Cancer Institute, Technical University of Denmark
- ZCZhigang C. Wang
Brigham and Women's Hospital, Fox Chase Cancer Center, Beth Israel Deaconess Medical Center, Harvard–MIT Division of Health Sciences and Technology, Dana-Farber Cancer Institute, Technical University of Denmark
- JKJi-Young Kim
Brigham and Women's Hospital, Fox Chase Cancer Center, Beth Israel Deaconess Medical Center, Harvard–MIT Division of Health Sciences and Technology, Dana-Farber Cancer Institute, Technical University of Denmark
- ACAron C. Eklund
Brigham and Women's Hospital, Fox Chase Cancer Center, Beth Israel Deaconess Medical Center, Harvard–MIT Division of Health Sciences and Technology, Dana-Farber Cancer Institute, CHA University, Technical University of Denmark
- QLQiyuan Li
Brigham and Women's Hospital, Fox Chase Cancer Center, Beth Israel Deaconess Medical Center, Harvard–MIT Division of Health Sciences and Technology, Dana-Farber Cancer Institute, Technical University of Denmark
Topics & keywords
- DNA
- Allele
- DNA repair
- Genetics
- Biology
- DNA damage
- Computational biology
- Molecular biology
- Good health and well-being