Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
The University of Sydney · Centenary Institute · +5 more institutions
Abstract
Abnormalities in CD4(+)CD25(+)Foxp3(+) regulatory T (T reg) cells have been implicated in susceptibility to allergic, autoimmune, and immunoinflammatory conditions. However, phenotypic and functional assessment of human T reg cells has been hampered by difficulty in distinguishing between CD25-expressing activated and regulatory T cells. Here, we show that expression of CD127, the alpha chain of the interleukin-7 receptor, allows an unambiguous flow cytometry-based distinction to be made between CD127(lo) T reg cells and CD127(hi) conventional T cells within the CD25(+)CD45RO(+)RA(-) effector/memory and CD45RA(+)RO(-) naive compartments in peripheral blood and lymph node. In healthy volunteers, peripheral…
Citation impact
- FWCI
- 39.59
- Percentile
- 100%
- References
- 30
Authors
12- NSNabila SeddikiCorresponding
The University of Sydney, Centenary Institute, St Vincent's Hospital Sydney
- BSBrigitte Santner‐Nanan
The University of Sydney, Western Sydney University
- JMJeff Martinson
Rush University Medical Center
- JZJohn Zaunders
St Vincent's Hospital Sydney
- SCSarah C. Sasson
St Vincent's Hospital Sydney
Topics & keywords
- IL-2 receptor
- Interleukin-7 receptor
- FOXP3
- Flow cytometry
- Biology
- Interleukin 21
- Immunology
- Population
- Reduced inequalities