VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism
University of Wisconsin–Madison · University of Göttingen · +1 more institution
Abstract
Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In Aspergillus nidulans, light inhibits sexual reproduction as well as secondary metabolism. We identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark, physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites.
Citation impact
- FWCI
- 34.69
- Percentile
- 100%
- References
- 25
Authors
11- ÖBÖzgür Bayram
University of Wisconsin–Madison, University of Göttingen, Deutsche Forschungsgemeinschaft
- SKSven KrappmannCorresponding
University of Wisconsin–Madison, University of Göttingen, Deutsche Forschungsgemeinschaft
- MNMin Ni
University of Wisconsin–Madison, University of Göttingen, Deutsche Forschungsgemeinschaft
- JWJin Woo Bok
University of Wisconsin–Madison, University of Göttingen, Deutsche Forschungsgemeinschaft
- KHKerstin Helmstaedt
University of Wisconsin–Madison, University of Göttingen, Deutsche Forschungsgemeinschaft
Topics & keywords
- Secondary metabolism
- Aspergillus nidulans
- Biology
- Heterotrimeric G protein
- Metabolism
- Secondary metabolite
- Cell biology
- Biochemistry