Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Baylor Institute for Rehabilitation · The University of Texas Southwestern Medical Center
Abstract
Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease characterized by flares of high morbidity. Using oligonucleotide microarrays, we now show that active SLE can be distinguished by a remarkably homogeneous gene expression pattern with overexpression of granulopoiesis-related and interferon (IFN)-induced genes. Using the most stringent statistical analysis (Bonferroni correction), 15 genes were found highly up-regulated in SLE patients, 14 of which are targets of IFN and one, defensin DEFA-3, a major product of immature granulocytes. A more liberal correction (Benjamini and Hochberg correction) yielded 18 additional genes, 12 of which are IFN-regulated and 4 granulocyte-specific.…
Citation impact
- FWCI
- 22.49
- Percentile
- 100%
- References
- 45
Authors
7- LBLynda BennettCorresponding
Baylor Institute for Rehabilitation, The University of Texas Southwestern Medical Center
- KPKarolina Palucka
Baylor Institute for Rehabilitation
- EAEdsel Arce
Baylor Institute for Rehabilitation, The University of Texas Southwestern Medical Center
- VAV. Ashley Cantrell
Baylor Institute for Rehabilitation, The University of Texas Southwestern Medical Center
- JBJosef Borvák
Baylor Institute for Rehabilitation
Topics & keywords
- Granulopoiesis
- Immunology
- Systemic lupus erythematosus
- Biology
- Cytokine
- Interferon
- Autoimmune disease
- Haematopoiesis
- Good health and well-being