The Genome Sequence of the SARS-Associated Coronavirus
BC Cancer Agency · University of Victoria · +2 more institutions
Abstract
We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)-associated coronavirus known as the Tor2 isolate. The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. The genome sequence will aid in the diagnosis of SARS virus infection in humans and potential animal hosts (using polymerase chain reaction and immunological tests), in the development of antivirals (including neutralizing antibodies), and in the…
Citation impact
- FWCI
- 356.04
- Percentile
- 100%
- References
- 24
Authors
59- MAMarco A. MarraCorresponding
BC Cancer Agency, University of Victoria, Canadian Science Centre for Human and Animal Health, BC Centre for Disease Control
- SJSteven J.M. Jones
BC Cancer Agency, University of Victoria, Canadian Science Centre for Human and Animal Health, BC Centre for Disease Control
- CRCaroline R. Astell
BC Cancer Agency, University of Victoria, Canadian Science Centre for Human and Animal Health, BC Centre for Disease Control
- RARobert A. Holt
BC Cancer Agency, University of Victoria, Canadian Science Centre for Human and Animal Health, BC Centre for Disease Control
- ABAngela Brooks‐Wilson
BC Cancer Agency, University of Victoria, Canadian Science Centre for Human and Animal Health, BC Centre for Disease Control
Topics & keywords
- Virology
- Biology
- Coronavirus
- Genome
- Virus
- Phylogenetic tree
- Whole genome sequencing
- Polymerase chain reaction
- Good health and well-being