Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
New York University Langone Orthopedic Hospital · University of California, San Francisco · +10 more institutions
Abstract
Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a combination of genetic and environmental factors. Animal models suggest a role for intestinal bacteria in supporting the systemic immune response required for joint inflammation. Here we performed 16S sequencing on 114 stool samples from rheumatoid arthritis patients and controls, and shotgun sequencing on a subset of 44 such samples. We identified the presence of Prevotella copri as strongly correlated with disease in new-onset untreated rheumatoid arthritis (NORA) patients. Increases in Prevotella abundance correlated with a reduction in Bacteroides and a loss of reportedly beneficial microbes in NORA subjects. We also…
Citation impact
- FWCI
- 44.72
- Percentile
- 100%
- References
- 55
Authors
12- JUJosé U. ScherCorresponding
New York University Langone Orthopedic Hospital
- ASAndrew Sczesnak
University of California, San Francisco, New York University
- RLRandy Longman
Cornell University, New York University
- NSNicola Segata
Boston University, Harvard University, University of Trento
- CÚCarles Úbeda
Memorial Sloan Kettering Cancer Center, Universitat de València
Topics & keywords
- Prevotella
- Bacteroides
- Immunology
- Rheumatoid arthritis
- Microbiome
- Biology
- Arthritis
- Disease