Interleukin-22: Immunobiology and Pathology

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs). Knowledge of IL-22 biology has evolved rapidly since its discovery in 2000, and a role for IL-22 has been identified in numerous tissues, including the intestines, lung, liver, kidney, thymus, pancreas, and skin. IL-22 primarily targets nonhematopoietic epithelial and stromal cells, where it can promote proliferation and play a role in tissue regeneration. In addition, IL-22 regulates host defense at barrier surfaces. However, IL-22 has also been linked to several conditions involving inflammatory tissue pathology. In this…

• AL
  Alex's Lemonade Stand Foundation for Childhood Cancer
• MS
  Memorial Sloan-Kettering Cancer Center

  Award: P01-CA023766
• GB
  Geoffrey Beene Cancer Research Center
• AS
  American Society for Blood and Marrow Transplantation
• EC
  European Commission
• NI
  National Institutes of Health

  Awards: R01-AI100288, R01-AI101406, R01-AI080455, K08-HL115355, R01-HL069929, P01-CA023766, CA023766
• MR
  Medical Research Council
• NH
  National Health and Medical Research Council
• NI
  National Institute of Allergy and Infectious Diseases

  Awards: HHSN272200900059C, R01-AI101406