Frequency and Evolution of Azole Resistance in Aspergillus fumigatus Associated with Treatment Failure1
Universidade Federal do Rio Grande do Sul · Imperial College London · +5 more institutions
Abstract
Azoles are the mainstay of oral therapy for aspergillosis. Azole resistance in Aspergillus has been reported infrequently. The first resistant isolate was detected in 1999 in Manchester, UK. In a clinical collection of 519 A. fumigatus isolates, the frequency of itraconazole resistance was 5%, a significant increase since 2004 (p
Citation impact
- FWCI
- 25.87
- Percentile
- 100%
- References
- 39
Authors
10- SJSusan J. HowardCorresponding
Universidade Federal do Rio Grande do Sul, Imperial College London, University of Manchester, Ljubljana University Medical Centre, Manchester Academic Health Science Centre, Hôpital Maisonneuve-Rosemont, Statens Serum Institut
- DCDaša Cerar
Hôpital Maisonneuve-Rosemont, Manchester Academic Health Science Centre, Statens Serum Institut, University of Manchester, Imperial College London, Ljubljana University Medical Centre, Universidade Federal do Rio Grande do Sul
- MJMichael J. Anderson
Ljubljana University Medical Centre, Hôpital Maisonneuve-Rosemont, Universidade Federal do Rio Grande do Sul, Imperial College London, University of Manchester, Manchester Academic Health Science Centre, Statens Serum Institut
- AAAhmed Albarrag
Statens Serum Institut, Ljubljana University Medical Centre, Imperial College London, Hôpital Maisonneuve-Rosemont, Manchester Academic Health Science Centre, Universidade Federal do Rio Grande do Sul, University of Manchester
- MCMatthew C. Fisher
Ljubljana University Medical Centre, Statens Serum Institut, Manchester Academic Health Science Centre, Hôpital Maisonneuve-Rosemont, University of Manchester, Imperial College London, Universidade Federal do Rio Grande do Sul
Topics & keywords
- Posaconazole
- Itraconazole
- Aspergillus fumigatus
- Voriconazole
- Azole
- Microbiology
- Aspergillosis
- Drug resistance
- Good health and well-being