Whole brain resting-state analysis reveals decreased functional connectivity in major depression

Recently, both increases and decreases in resting-state functional connectivity have been found in major depression. However, these studies only assessed functional connectivity within a specific network or between a few regions of interest, while comorbidity and use of medication was not always controlled for. Therefore, the aim of the current study was to investigate whole-brain functional connectivity, unbiased by a priori definition of regions or networks of interest, in medication-free depressive patients without comorbidity. We analyzed resting-state fMRI data of 19 medication-free patients with a recent diagnosis of major depression (within 6 months before inclusion) and no comorbidity, and 19 age- and…

• Z
  ZonMw
• VU
  Vrije Universiteit Amsterdam
• GI
  GGZ inGeest
• R
  Rivierduinen
• GF
  GGZ Friesland
• GD
  GGZ Drenthe
• NI
  Nederlands Instituut voor Onderzoek van de Gezondheidszorg
• LU
  Leids Universitair Medisch Centrum
• UM
  Universitair Medisch Centrum Groningen