Mesenchymal Stem Cells as Therapeutics
Shriners Hospitals for Children - Erie · Harvard University · +3 more institutions
Abstract
Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as a new therapeutic for treating a variety of immune-mediated diseases. First heralded as a regenerative therapy for skeletal tissue repair, MSCs have recently been shown to modulate endogenous tissue and immune cells. Preclinical studies of the mechanism of action suggest that the therapeutic effects afforded by MSC transplantation are short-lived and related to dynamic, paracrine interactions between MSCs and host cells. Therefore, representations of MSCs as drug-loaded particles may allow for pharmacokinetic models to predict the therapeutic activity of MSC transplants as a function of drug delivery mode. By integrating…
Citation impact
- FWCI
- 21.77
- Percentile
- 100%
- References
- 191
Authors
2- BPBiju ParekkadanCorresponding
Shriners Hospitals for Children - Erie, Harvard University, Massachusetts General Hospital
- JMJack M. Milwid
Shriners Hospitals for Children - Erie, Harvard University, Massachusetts General Hospital, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology
Topics & keywords
- Mesenchymal stem cell
- Stem cell
- Regenerative medicine
- Immune system
- Paracrine signalling
- Transplantation
- Clinical uses of mesenchymal stem cells
- Medicine
- Good health and well-being