Preconditioning of Low-Frequency Repetitive Transcranial Magnetic Stimulation with Transcranial Direct Current Stimulation: Evidence for Homeostatic Plasticity in the Human Motor Cortex
Christian-Albrechts-Universität zu Kiel · University College London · +2 more institutions
Abstract
Recent experimental work in animals has emphasized the importance of homeostatic plasticity as a means of stabilizing the properties of neuronal circuits. Here, we report a phenomenon that indicates a homeostatic pattern of cortical plasticity in healthy human subjects. The experiments combined two techniques that can produce long-term effects on the excitability of corticospinal output neurons: transcranial direct current stimulation (TDCS) and repetitive transcranial magnetic stimulation (rTMS) of the left primary motor cortex. "Facilitatory preconditioning" with anodal TDCS caused a subsequent period of 1 Hz rTMS to reduce corticospinal excitability to below baseline levels for >20 min. Conversely,…
Citation impact
- FWCI
- 21.51
- Percentile
- 100%
- References
- 55
Authors
7- HRHartwig R. SiebnerCorresponding
Christian-Albrechts-Universität zu Kiel, University College London
- NLNicolas Lang
University College London, University of Göttingen
- VRVincenzo Rizzo
University of Messina, University College London
- MAMichael A. Nitsche
University of Göttingen
- WPWalter Paulus
University of Göttingen
Topics & keywords
- Transcranial magnetic stimulation
- Neuroscience
- Transcranial direct-current stimulation
- Motor cortex
- Neuroplasticity
- Primary motor cortex
- Stimulation
- Psychology
- Good health and well-being