articleJournal of Clinical OncologyJan 19, 2011BRONZE OA

Histopathologic-Based Prognostic Factors of Colorectal Cancers Are Associated With the State of the Local Immune Reaction

BMBernhard MlecnikMTMarie TosoliniAKAmos KirilovskyABAnne BergerGBGabriela Bindea

Inserm · Université Paris Cité · +4 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

PURPOSE: The prognosis of patients with colorectal cancer has sometimes proved uncertain; thus, the prognostic significance of immune criteria was compared with that of the tumor extension criteria using the American Joint Committee on Cancer/International Union Against Cancer-TNM (AJCC/UICC-TNM) staging system. PATIENTS AND METHODS: We studied the intratumoral immune infiltrates in the center of the tumor and in the invasive margin of 599 specimens of stage I to IV colorectal cancers from two independent cohorts. We analyzed these findings in relation to the degree of tumor extension and to the frequency of recurrence. RESULTS: Growth of the primary tumor and metastatic spread were associated with decreased…

Citation impact

992
total citations
FWCI
25.83
Percentile
100%
References
43
Citations per year

Authors

11

Topics & keywords

Topics
Keywords
  • Medicine
  • Colorectal cancer
  • Stage (stratigraphy)
  • Immune system
  • Oncology
  • Hazard ratio
  • Internal medicine
  • Univariate analysis
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding