The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells
University of Michigan–Ann Arbor · California Institute for Regenerative Medicine · +1 more institution
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Abstract
Background
Breast cancers contain a minority population of cancer cells characterized by CD44 expression but low or undetectable levels of CD24 (CD44+CD24-/low) that have higher tumorigenic capacity than other subtypes of cancer cells.
Methods
We compared the gene-expression profile of CD44+CD24-/low tumorigenic breast-cancer cells with that of normal breast epithelium. Differentially expressed genes were used to generate a 186-gene "invasiveness" gene signature (IGS), which was evaluated for its association with overall survival and metastasis-free survival in patients with breast cancer or other types of cancer.
Citation impact
988
total citations
- FWCI
- 55.29
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- 100%
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- 17
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Authors
10Topics & keywords
Topics
Keywords
- Breast cancer
- Medicine
- Oncology
- Metastasis
- CD44
- Gene signature
- Internal medicine
- Cancer
UN Sustainable Development Goals
- Good health and well-being
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