Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype
University of Perugia · European Institute of Oncology · +6 more institutions
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Abstract
Background
Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations involving the NPM gene cause cytoplasmic dislocation of the NPM protein.
Methods
We used immunohistochemical methods to study the subcellular localization of NPM in bone marrow-biopsy specimens from 591 patients with primary acute myelogenous leukemia (AML). We then correlated the presence of cytoplasmic NPM with clinical and biologic features of the disease.
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Authors
23Topics & keywords
Topics
Keywords
- Nucleophosmin
- Cytoplasm
- Cancer research
- NPM1
- Biology
- Leukemia
- Karyotype
- Bone marrow
UN Sustainable Development Goals
- Good health and well-being
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