Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery
Centre National de la Recherche Scientifique · University of Trieste · +4 more institutions
Abstract
Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA–nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.
Citation impact
- FWCI
- 15.67
- Percentile
- 100%
- References
- 30
Authors
8- DPDavide Pantarotto
Centre National de la Recherche Scientifique, University of Trieste, Immunologie, Immunopathologie et Chimie Thérapeutique, Institut de Biologie Moléculaire et Cellulaire
- RSRavi Singh
University of London
- DMDavid McCarthy
University of London
- MEMathieu Erhardt
Institut de Biologie Moléculaire des Plantes
- JBJean‐Paul Briand
Centre National de la Recherche Scientifique, Immunologie, Immunopathologie et Chimie Thérapeutique, Institut de Biologie Moléculaire et Cellulaire
Topics & keywords
- Carbon nanotube
- Gene delivery
- DNA
- Nanotechnology
- Plasmid
- Genetic enhancement
- Gene
- Materials science