Photocrosslinkable Gelatin Hydrogel for Epidermal Tissue Engineering
Brigham and Women's Hospital · Harvard University · +9 more institutions
Abstract
Natural hydrogels are promising scaffolds to engineer epidermis. Currently, natural hydrogels used to support epidermal regeneration are mainly collagen- or gelatin-based, which mimic the natural dermal extracellular matrix but often suffer from insufficient and uncontrollable mechanical and degradation properties. In this study, a photocrosslinkable gelatin (i.e., gelatin methacrylamide (GelMA)) with tunable mechanical, degradation, and biological properties is used to engineer the epidermis for skin tissue engineering applications. The results reveal that the mechanical and degradation properties of the developed hydrogels can be readily modified by varying the hydrogel concentration, with elastic and…
Citation impact
- FWCI
- 19.83
- Percentile
- 100%
- References
- 63
Authors
10- XZXin Zhao
Brigham and Women's Hospital, Harvard University, University of Nottingham, Harvard–MIT Division of Health Sciences and Technology, Innovation Research Center, Queen's Medical Centre, Massachusetts Institute of Technology
- QLQi Lang
Brigham and Women's Hospital, Harvard University, Harvard–MIT Division of Health Sciences and Technology, Innovation Research Center, Massachusetts Institute of Technology
- LYLara Yildirimer
Brigham and Women's Hospital, Harvard University, Harvard–MIT Division of Health Sciences and Technology, Innovation Research Center, Massachusetts Institute of Technology
- ZYZhi Yuan Lin
Brigham and Women's Hospital, Harvard University, Harvard–MIT Division of Health Sciences and Technology, Innovation Research Center, Massachusetts Institute of Technology
- WCWenguo Cui
Soochow University
Topics & keywords
- Self-healing hydrogels
- Gelatin
- Materials science
- Tissue engineering
- Epidermis (zoology)
- Extracellular matrix
- Keratinocyte
- Biomedical engineering