TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
Tohoku University · Yale University · +4 more institutions
Abstract
TGF-beta-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key modulator of the inducible transcription factors NF-kappaB and AP-1 and, therefore, plays a crucial role in regulating the genes that mediate inflammation. Although in vitro biochemical studies have revealed the existence of a TAK1 complex, which includes TAK1 and the adapter proteins TAB1 and TAB2, it remains unclear which members of this complex are essential for signaling. To analyze the function of TAK1 in vivo, we have deleted the Tak1 gene in mice, with the resulting phenotype being early embryonic lethality. Using embryonic fibroblasts lacking TAK1, TAB1, or TAB2, we have found that TNFR1, IL-1R, TLR3, and…
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- References
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Authors
14- JSJae‐Hyuck ShimCorresponding
Tohoku University, Yale University, Japan Science and Technology Agency, Nagoya University, Kumamoto University, The University of Osaka
- CXChangchun Xiao
Tohoku University, Yale University, Japan Science and Technology Agency, Nagoya University, Kumamoto University, The University of Osaka
- APAmber Paschal
Tohoku University, Yale University, Japan Science and Technology Agency, Nagoya University, Kumamoto University, The University of Osaka
- STShannon T. Bailey
Tohoku University, Yale University, Japan Science and Technology Agency, Nagoya University, Kumamoto University, The University of Osaka
- PNP. Nagesh Rao
Tohoku University, Yale University, Japan Science and Technology Agency, Nagoya University, Kumamoto University, The University of Osaka
Topics & keywords
- Biology
- Cell biology
- IκB kinase
- Signal transduction
- TRAF2
- Kinase
- MAP kinase kinase kinase
- NF-κB
- Good health and well-being