reviewAnnual Review of MicrobiologyOct 15, 2015BRONZE OA

Candida albicans Biofilms and Human Disease

CJClarissa J. NobileADAlexander D. Johnson

University of California, Merced · University of California, San Francisco

PubMed
Indexed incrossrefpubmed

Abstract

In humans, microbial cells (including bacteria, archaea, and fungi) greatly outnumber host cells. Candida albicans is the most prevalent fungal species of the human microbiota; this species asymptomatically colonizes many areas of the body, particularly the gastrointestinal and genitourinary tracts of healthy individuals. Alterations in host immunity, stress, resident microbiota, and other factors can lead to C. albicans overgrowth, causing a wide range of infections, from superficial mucosal to hematogenously disseminated candidiasis. To date, most studies of C. albicans have been carried out in suspension cultures; however, the medical impact of C. albicans (like that of many other microorganisms) depends on…

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1,031
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Authors

2

Topics & keywords

Topics
Keywords
  • Biofilm
  • Candida albicans
  • Microbiology
  • Corpus albicans
  • Biology
  • Immune system
  • Human microbiome
  • Bacteria
UN Sustainable Development Goals
  • Life in Land
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