Metal–Organic Frameworks as Efficient Materials for Drug Delivery

Fill 'em up: The metal carboxylates MIL-100 and MIL-101 act as porous matrices (see picture; MIL=Materials of Institut Lavoisier) for drug-delivery systems using Ibuprofen as a model substrate. Very large amounts of the drug could be incorporated, up to an unprecedented capacity of 1.4 g of drug per gram of porous solid for MIL-101, and the total release of Ibuprofen was achieved under physiological conditions in 3 (MIL-100) and 6 days (MIL-101). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z601878_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied…