Aquaporins in the Kidney: From Molecules to Medicine
National Institutes of Health · University of Leeds · +5 more institutions
Abstract
The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical question of how water specifically crosses biological membranes. In the kidney, at least seven aquaporins are expressed at distinct sites. AQP1 is extremely abundant in the proximal tubule and descending thin limb and is essential for urinary concentration. AQP2 is exclusively expressed in the principal cells of the connecting tubule and collecting duct and is the predominant vasopressin-regulated water channel. AQP3 and AQP4 are both present in the basolateral plasma membrane of collecting duct principal cells and represent exit pathways for water reabsorbed apically via AQP2. Studies in patients and transgenic mice have demonstrated…
Citation impact
- FWCI
- 23.00
- Percentile
- 100%
- References
- 274
Authors
6- SNSøren NielsenCorresponding
National Institutes of Health, University of Leeds, Johns Hopkins University, Dongguk University, Johns Hopkins Medicine, National Heart Lung and Blood Institute, Dongguk University WISE
- JFJørgen Frøkiær
National Institutes of Health, University of Leeds, Johns Hopkins University, Dongguk University, Johns Hopkins Medicine, National Heart Lung and Blood Institute, Dongguk University WISE
- DMDavid Marples
National Institutes of Health, University of Leeds, Johns Hopkins University, Dongguk University, Johns Hopkins Medicine, National Heart Lung and Blood Institute, Dongguk University WISE
- TKTae‐Hwan Kwon
National Institutes of Health, University of Leeds, Johns Hopkins University, Dongguk University, Johns Hopkins Medicine, National Heart Lung and Blood Institute, Dongguk University WISE
- PAPeter Agre
National Institutes of Health, University of Leeds, Johns Hopkins University, Dongguk University, Johns Hopkins Medicine, National Heart Lung and Blood Institute, Dongguk University WISE
Topics & keywords
- Aquaporin 2
- Aquaporin
- Aquaporin 3
- Reabsorption
- Apical membrane
- Kidney
- Cell biology
- Vasopressin