Carbon Monoxide-Releasing Molecules
Northwick Park Institute for Medical Research · University of Sheffield
Abstract
Carbon monoxide (CO) is generated in living organisms during the degradation of heme by the enzyme heme oxygenase, which exists in constitutive (HO-2 and HO-3) and inducible (HO-1) isoforms. Carbon monoxide gas is known to dilate blood vessels in a manner similar to nitric oxide and has been recently shown to possess antiinflammatory and antiapoptotic properties. We report that a series of transition metal carbonyls, termed here carbon monoxide-releasing molecules (CO-RMs), liberate CO to elicit direct biological activities. Specifically, spectrophotometric and NMR analysis revealed that dimanganese decacarbonyl and tricarbonyldichlororuthenium (II) dimer release CO in a concentration-dependent manner.…
Citation impact
- FWCI
- 8.86
- Percentile
- 100%
- References
- 34
Authors
6- RMRoberto MotterliniCorresponding
Northwick Park Institute for Medical Research, University of Sheffield
- JCJames Clark
Northwick Park Institute for Medical Research, University of Sheffield
- RFRoberta Foresti
Northwick Park Institute for Medical Research, University of Sheffield
- PSPadmini Sarathchandra
Northwick Park Institute for Medical Research, University of Sheffield
- BEBrian E. Mann
Northwick Park Institute for Medical Research, University of Sheffield
Topics & keywords
- Carbon monoxide
- Heme oxygenase
- Heme
- Chemistry
- Hemin
- Nitric oxide
- Vasoconstriction
- Vasodilation
- Clean water and sanitation