articleRNAFeb 8, 2005BRONZE OA

Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes

SBScott BaskervilleDPDavid P. Bartel

Whitehead Institute for Biomedical Research · Massachusetts Institute of Technology

Indexed incrossref

Abstract

MicroRNAs (miRNAs) are short endogenous RNAs known to post-transcriptionally repress gene expression in animals and plants. A microarray profiling survey revealed the expression patterns of 175 human miRNAs across 24 different human organs. Our results show that proximal pairs of miRNAs are generally coexpressed. In addition, an abrupt transition in the correlation between pairs of expressed miRNAs occurs at a distance of 50 kb, implying that miRNAs separated by <50 kb typically derive from a common transcript. Some microRNAs are within the introns of host genes. Intronic miRNAs are usually coordinately expressed with their host gene mRNA, implying that they also generally derive from a common transcript,…

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Topics & keywords

Topics
Keywords
  • Biology
  • microRNA
  • Gene
  • Gene expression profiling
  • Genetics
  • Gene expression
  • DNA microarray
  • Intron
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