Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease
Alzheimer's Association · Translational Genomics Research Institute · +9 more institutions
Abstract
Fibrillar amyloid-beta (Abeta) is found in the brains of many cognitively normal older people. Whether or not this reflects a predisposition to Alzheimer's disease (AD) is unknown. We used Pittsburgh Compound B (PiB) PET to characterize the relationship between fibrillar Abeta burden and this predisposition in cognitively normal older people at 3 mean levels of genetic risk for AD. Dynamic PiB PET scans, the Logan method, statistical parametric mapping, and automatically labeled regions of interest (ROIs) were used to characterize and compare cerebral-to-cerebellar PIB distribution volume ratios, reflecting fibrillar Abeta burden, in 28 cognitively normal persons (mean age, 64 years) with a reported family…
Citation impact
- FWCI
- 40.34
- Percentile
- 100%
- References
- 44
Authors
17- EMEric M. ReimanCorresponding
Alzheimer's Association, Translational Genomics Research Institute, Good Samaritan Medical Center, Good Samaritan Regional Medical Center, Arizona Alzheimer’s Consortium
- KCKewei Chen
Alzheimer's Association, Good Samaritan Medical Center, Good Samaritan Regional Medical Center, University Radiology, Arizona Alzheimer’s Consortium
- XLXiaofen Liu
Alzheimer's Association, Good Samaritan Medical Center, Good Samaritan Regional Medical Center, Arizona Alzheimer’s Consortium
- DBDaniel Bandy
Alzheimer's Association, Good Samaritan Medical Center, Good Samaritan Regional Medical Center, Arizona Alzheimer’s Consortium
- MYMeixiang Yu
Alzheimer's Association, Good Samaritan Medical Center, Good Samaritan Regional Medical Center, Arizona Alzheimer’s Consortium, Arizona State University
Topics & keywords
- Precuneus
- Apolipoprotein E
- Posterior cingulate
- Pittsburgh compound B
- Alzheimer's disease
- Cognitive decline
- Genetic predisposition
- Risk factor
- Good health and well-being