KEGG for representation and analysis of molecular networks involving diseases and drugs
Kyoto University · Japan Science and Technology Agency · +2 more institutions
Abstract
Most human diseases are complex multi-factorial diseases resulting from the combination of various genetic and environmental factors. In the KEGG database resource (http://www.genome.jp/kegg/), diseases are viewed as perturbed states of the molecular system, and drugs as perturbants to the molecular system. Disease information is computerized in two forms: pathway maps and gene/molecule lists. The KEGG PATHWAY database contains pathway maps for the molecular systems in both normal and perturbed states. In the KEGG DISEASE database, each disease is represented by a list of known disease genes, any known environmental factors at the molecular level, diagnostic markers and therapeutic drugs, which may reflect the…
Citation impact
- FWCI
- 113.74
- Percentile
- 100%
- References
- 18
Authors
5- MKMinoru KanehisaCorresponding
Kyoto University, Japan Science and Technology Agency, Tokyo University of Science, Kyoto University Institute for Chemical Research
- SGSusumu Goto
Kyoto University, Tokyo University of Science, Japan Science and Technology Agency
- MFMiho Furumichi
Kyoto University, Japan Science and Technology Agency, Tokyo University of Science
- MTMao Tanabe
Japan Science and Technology Agency, Tokyo University of Science, Kyoto University
- MHMika Hirakawa
Kyoto University, Tokyo University of Science, Japan Science and Technology Agency
Topics & keywords
- KEGG
- Computational biology
- Biology
- Disease
- Bioinformatics
- Database
- Computer science
- Gene