Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora

Strong and selective cytotoxicity toward a variety of cancer cell lines is shown by salinosporamide A (1), which was isolated from the culture extract of a unique marine actinomycete belonging to the recently discovered genus Salinospora. We recently reported the cultivation and phylogenetic characterization of a new group of obligate marine actinomycete bacteria that is widely distributed in ocean sediments.1 Analogous soil-derived actinomycetes have been the single most significant source of naturally occurring microbial antibiotics,2 thus the discovery of a major new group of these bacteria in marine sediments suggests that the ocean represents an overlooked habitat from which to isolate these important…

• NI
  National Institutes of Health

  Award: CA44848
• UO
  University of California, San Diego
• NC
  National Cancer Institute

  Award: CA44848