Changes in Forced Expiratory Volume in 1 Second over Time in COPD
Manchester Academic Health Science Centre · Hvidovre Hospital · +18 more institutions
Abstract
A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated rate of decline in forced expiratory volume in 1 second (FEV(1)), but data on the variability and determinants of this change in patients who have established disease are scarce.
We analyzed the changes in FEV(1) after administration of a bronchodilator over a 3-year period in 2163 patients. A random-coefficient model was used to evaluate possible predictors of both FEV(1) levels and their changes over time.
Citation impact
- FWCI
- 61.72
- Percentile
- 100%
- References
- 25
Authors
17- JVJørgen VestboCorresponding
Manchester Academic Health Science Centre, Hvidovre Hospital, University of Copenhagen, University of Manchester, Health Sciences Centre
- LELisa Edwards
Research Triangle Park Foundation, GlaxoSmithKline (United States)
- PDPaul D. Scanlon
Mayo Clinic in Arizona
- JYJulie Yates
GlaxoSmithKline (United States), Research Triangle Park Foundation
- ÀAÀlvar Agustí
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Universitat de Barcelona
Topics & keywords
- Medicine
- COPD
- Bronchodilator
- Pulmonary disease
- Anesthesia
- Internal medicine
- Cardiology
- Asthma
- Good health and well-being