TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation
University of Alabama at Birmingham · Zhejiang University · +2 more institutions
Abstract
Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is involved in a vast majority of cellular processes and is fundamentally important throughout life. TGF-β/BMPs have widely recognized roles in bone formation during mammalian development and exhibit versatile regulatory functions in the body. Signaling transduction by TGF-β/BMPs is specifically through both canonical Smad-dependent pathways (TGF-β/BMP ligands, receptors and Smads) and non-canonical Smad-independent signaling pathway (e.g. p38 mitogen-activated protein kinase pathway, MAPK). Following TGF-β/BMP induction, both the Smad and p38 MAPK pathways converge at the Runx2 gene to control mesenchymal precursor cell…
Citation impact
- FWCI
- 39.50
- Percentile
- 100%
- References
- 183
Authors
3- GCGuiqian ChenCorresponding
University of Alabama at Birmingham, Zhejiang University
- CDChuxia Deng
National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
- YLYiping Li
University of Alabama at Birmingham, Zhejiang University
Topics & keywords
- SMAD
- BMPR2
- Osteoblast
- Wnt signaling pathway
- Bone morphogenetic protein
- RUNX2
- Cell biology
- Signal transduction